Thermo Fisher Scientific GRK2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human GRK2 (ADRBK1) for Western blot applications. Recognizes recombinant fragment within amino acids 1–358. High predicted cross-reactivity with mouse, rat, pig, and bovine. Supplied as liquid, 0.9 mg/mL, unconjuga...
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific GRK2 Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–358 of Human GRK2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.9 mg/mL |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546055 |
Product Specific Information
- Recommended positive controls: 293T, U87-MG, MCF-7
- Predicted reactivity: Mouse (98%), Rat (97%), Pig (96%), Bovine (97%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
ADRBK1 (GRK2) is a serine/threonine kinase involved in phosphorylation of G protein-coupled receptors (GPCRs). GRK2 (83 kDa) is one of six GRK family members and is ubiquitously expressed in mammals. Upon ligand binding, GPCRs are phosphorylated by GRKs, leading to internalization mediated by beta-arrestin-1 and activation of the Ras–Raf–ERK1/2 signaling pathway. GRK2 activity is regulated by phosphorylation via PKC, Src, and ERK1/2, as well as protein interactions. ERK phosphorylates GRK2 on serine 670, inactivating it through a negative feedback mechanism.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-28579_GRK2_P25098-1_Rabbit.svg, PA5-28579_GRK2_P25098-1_Rabbit_PDP.jpeg)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.