Thermo Fisher Scientific Phospho-c-Myc (Ser62) Polyclonal Antibody
Phospho-c-Myc (Ser62) 폴리클로날 항체로 인간, 생쥐, 랫트 시료에 반응. Western blot, IHC, ELISA에 최적화. 세포 증식 및 종양 관련 신호전달 연구에 적합. 고순도 친화성 크로마토그래피 정제 항체.
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Thermo Fisher Scientific Phospho-c-Myc (Ser62) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A phospho-specific peptide corresponding to residues surrounding S62 of human MYC (NP_001341799.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.32 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901808 |
Product Specific Information
- Positive Samples: NIH/3T3
- Immunogen Sequence: PLSPSR
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a key role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK is associated with cell proliferation and regulation.
c-Myc is essential for vasculogenesis and angiogenesis in tumor development. Deregulated expression of c-Myc can induce apoptosis and is linked to multiple human cancers, including lung, breast, and colon carcinomas.
Translocation of the c-Myc locus on chromosome 8 to immunoglobulin loci on chromosomes 14, 2, or 22 is characteristic of Burkitt’s lymphoma and other B-cell proliferative diseases. Aberrant expression of c-Myc occurs in a wide range of tumors from various tissues.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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