Thermo Fisher Scientific Phospho-c-Myc (Ser62) Polyclonal Antibody
Phospho-c-Myc (Ser62) 폴리클로날 항체로 인간, 생쥐, 랫트 시료에 반응. Western blot, IHC, ELISA에 최적화. 세포 증식 및 종양 관련 신호전달 연구에 적합. 고순도 친화성 크로마토그래피 정제 항체.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-c-Myc (Ser62) Polyclonal Antibody
Thermo Fisher Scientific Phospho-c-Myc (Ser62) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A phospho-specific peptide corresponding to residues surrounding S62 of human MYC (NP_001341799.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.32 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901808 |
Product Specific Information
- Positive Samples: NIH/3T3
- Immunogen Sequence: PLSPSR
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a key role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK is associated with cell proliferation and regulation.
c-Myc is essential for vasculogenesis and angiogenesis in tumor development. Deregulated expression of c-Myc can induce apoptosis and is linked to multiple human cancers, including lung, breast, and colon carcinomas.
Translocation of the c-Myc locus on chromosome 8 to immunoglobulin loci on chromosomes 14, 2, or 22 is characteristic of Burkitt’s lymphoma and other B-cell proliferative diseases. Aberrant expression of c-Myc occurs in a wide range of tumors from various tissues.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.