Thermo Fisher Scientific ATXN7L3 Polyclonal Antibody
Human ATXN7L3 단백질에 특이적인 Rabbit Polyclonal 항체로, Western blot 및 Immunoprecipitation에 적합합니다. 보존제가 없으며, 장기 보관 시 -20°C에서 보관 권장. SAGA 복합체 관련 전사 조절 연구에 활용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 4–8 µL/mg of lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the center region of Human ATXN7L3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787689 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human ATXN7L3.
Target Information
ATXN7L3 is a component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, ATXN7L3 participates in a subcomplex that specifically deubiquitinates histones H2A and H2B (PubMed:18206972, PubMed:21746879).
The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription and nuclear receptor-mediated transactivation. Within the complex, ATXN7L3 is required to recruit USP22 and ENY2 into the SAGA complex (PubMed:18206972). It regulates H2B monoubiquitination (H2Bub1) levels and affects the subcellular distribution of ENY2, USP22, and ATXN7L3B (PubMed:27601583). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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