Thermo Fisher Scientific SETD8 Polyclonal Antibody
SETD8 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P)에서 검증됨. 인간, 생쥐, 랫트에 반응하며, 액상 형태로 제공. Affinity chromatography로 정제되어 높은 특이성과 재현성을 보장. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KMT5A (Accession Q9NQR1), corresponding to amino acid residues E74–C124 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852106 |
Product Specific Information
Antibody detects endogenous levels of total KMT5A.
Target Information
SETD8 is a histone methyltransferase that specifically monomethylates Lys-20 of histone H4. H4 Lys-20 monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. The protein mainly functions in euchromatin regions, thereby playing a central role in silencing euchromatic genes. It is required for cell proliferation by maintaining proper higher-order DNA structure during mitosis and is also involved in chromosome condensation and cytokinesis. Nucleosomes are preferred as substrates compared to free histones.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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