Thermo Fisher Scientific Human ULK1 Synthetic Peptide
Human ULK1 단백질의 중심부 16개 아미노산 서열로 구성된 합성 펩타이드로, PA5-34542 항체의 블로킹 펩타이드로 사용 가능. Western blot 등 다양한 실험에서 활용되며, PBS(pH 7.2) 버퍼 내 0.1% BSA와 0.02% sodium azide 포함. 연구용으로만 사용.
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Thermo Fisher Scientific Human ULK1 Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 16 amino acids near the center of human ULK1.
PEP-1585 can be used as a blocking peptide with polyclonal antibody PA5-34542.
For use as a blocking peptide in Western blot, incubate the peptide with equal volume of antibody for 30 min at 37ºC.
Target Information
ULK1 is a serine/threonine protein kinase that plays a critical role during the initial stages of autophagy, a vital cellular response to nutrient starvation.
The conserved C-terminal domain (CTD) of ULK1 controls the regulatory function and localization of the protein.
Knockdown of ULK1 inhibits the autophagic response and rapamycin-induced autophagy, consistent with its role downstream of mTOR.
ULK1 forms a complex with FIP200 and ATG13, essential for starvation-induced autophagy.
Both FIP200 and ATG13 are critical for correct localization of ULK1 to the pre-autophagosome and for ULK1 protein stability.
ULK1 is phosphorylated by the mTOR pathway in a nutrient starvation-regulated manner.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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