Thermo Fisher Scientific HIV1 Rev Group M (subtype B) VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1422)

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

Assay-dependent

-

ELISA (ELISA)

Assay-dependent

-

Product Specifications

Species Reactivity

Virus

Host/Isotype

Alpaca / VHH

Expression System

CHO cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

SAA1422

Immunogen

Recombinant HIV-1 rev/ART/TRS.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Metal-chelate chromatography

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Product Specific Information

Compatible with Direct ELISA

Target Information

The HIV-1 Rev (regulator of expression of virion) protein is essential for the replication of HIV-1, especially in group M, which is the predominant and most widespread group of HIV-1 responsible for the global HIV epidemic. The Rev protein is encoded by the rev gene and plays a critical role in the nuclear export of unspliced and singly spliced viral mRNAs, which is crucial for the expression of structural proteins and the production of new virions. Structurally, Rev consists of an arginine-rich motif that allows it to bind to the Rev Response Element (RRE) within the viral RNA. This interaction facilitates the recruitment of the nuclear export receptor CRM1, which, along with other cofactors, translocates the RNA out of the nucleus. Functional disruption of Rev or its interaction with RRE significantly impedes HIV-1 replication, making these interactions potential targets for antiretroviral therapies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.