Thermo Fisher Scientific SENP8 Polyclonal Antibody
Human SENP8 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 IHC에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 시약이며, 1 mg/mL 농도. NEDD8 경로 조절 연구에 적합한 연구용 항체.
- 카탈로그번호
- PA529141
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region within amino acids 1–65 of Human SENP8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris Glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546617 |
Product Specific Information
- Recommended positive controls: 293T, H1299, HeLaS3, HepG2, Molt-4, Raji
- Predicted reactivity: Mouse (100%), Rhesus Monkey (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
SENP8 (Cysteine protease FKSG8; DEN1; FKSG8; HsT17512; NEDP1; PRSC2; SUMO/sentrin specific protease family member 8) is a novel cysteine protease belonging to the ULP family of deubiquitinases.
ULP family members consist of a C-terminal core catalytic domain and N-terminal extensions determining substrate specificity.
SENP8, a 24 kDa protein, plays a major role in regulating the NEDD8 pathway. It processes preNEDD8 to its mature form and deconjugates NEDD8 from substrates such as Cullins and p53.
SENP8 may help prevent accumulation of hyper-neddylated cullin and maintain mono-neddylated cullin levels, enhancing ubiquitination efficiency by SCF ubiquitin ligases.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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