Thermo Fisher Scientific PIASy Polyclonal Antibody
PIASy 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 신뢰성을 제공. 연구용으로만 사용 가능.
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Thermo Fisher Scientific PIASy Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 441–494 of Human PIASy |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546622 |
Product Specific Information
- Recommended positive control: human PIAS4-transfected 293T cells
- Predicted reactivity: Chimpanzee (100%), Bovine (100%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
Target Information
PIASy functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and substrates, and as a SUMO-tethering factor.
It plays a key role in transcriptional coregulation within cellular pathways such as STAT, p53/TP53, Wnt, and steroid hormone signaling.
PIASy mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4, and RNF168, represses LEF1, and enhances TCF4 transcriptional activities through sumoylation.
It also enhances MTA1 sumoylation and may participate in paralog-selective sumoylation.
[Source: UniProt]
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
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