Thermo Fisher Scientific MMP2/Collagenase Type IV A (Tumor Metastasis Marker) Monoclonal Antibody (MMP2/1501)
인간 MMP2 단백질을 인식하는 단클론 항체로, 종양 전이 및 콜라겐 분해 연구에 적합합니다. Western blot 및 Peptide array에 사용 가능하며, 고순도 Protein A/G 정제 제품입니다. 액상 형태로 4°C 보관, 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MMP2/1501 |
| Immunogen | Recombinant human MMP2 protein fragment (aa 444–575) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Matrix metalloproteinases (MMPs) are proteolytic enzymes capable of degrading connective tissue components. They share a conserved activation mechanism and metal-binding site, and are regulated by tissue inhibitors of metalloproteinases (TIMPs). MMP2 is synthesized as a 631 amino acid proenzyme that becomes active after cleavage of the first 80 amino acids. It contains propeptide, catalytic, and hemopexin domains. MMP2 plays a key role in tissue remodeling, angiogenesis, and extracellular matrix degradation. Mutations in the MMP2 gene are associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP2 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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