Thermo Fisher Scientific CD10 (Membrane Metalloendopeptidase) Recombinant Rabbit Monoclonal Antibody (MME/8658R)

Thermo Fisher Scientific CD10 (Membrane Metalloendopeptidase) Recombinant Rabbit Monoclonal Antibody (MME/8658R)

Applications

• Immunohistochemistry (PFA fixed) (IHC (PFA))

Tested Dilution: 1–2 µg/mL

Product Specifications

Target Information

CD10 (Common Acute Lymphocytic Leukemia Antigen, CALLA) is a cell surface enzyme with neutral metalloendopeptidase activity that inactivates various biologically active peptides. It is expressed on lymphoblastic, Burkitt’s, and follicular germinal center lymphoma cells, immature B cells in adult bone marrow, and cells from patients with chronic myelocytic leukemia (CML). CD10 is also found on breast myoepithelial cells, bile canaliculi, fibroblasts, and highly expressed on the brush border of kidney and gut epithelial cells.

CD10 functions as a neutral endopeptidase, cleaving peptides at the amino side of hydrophobic residues and inactivating peptide hormones such as glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. It is a 100 kDa type II transmembrane glycoprotein encoded by a single-copy gene (~45 kb). The gene’s 5′ untranslated region undergoes alternative splicing, producing four separate mRNA transcripts without affecting the coding region.

Diseases associated with CD10 dysfunction include spinocerebellar ataxia 43 and Charcot-Marie-Tooth disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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