Thermo Fisher Scientific CD10 (Membrane Metalloendopeptidase) Recombinant Rabbit Monoclonal Antibody (MME/8658R)
Recombinant rabbit monoclonal antibody against human CD10 (MME), validated for IHC (PFA fixed). High specificity and purity via Protein A/G purification. Supplied as liquid at 200 µg/mL in PBS buffer with BSA and sodium azide. For research use only.
- 카탈로그번호
- 4311-RBM41-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD10 (Membrane Metalloendopeptidase) Recombinant Rabbit Monoclonal Antibody (MME/8658R)
Thermo Fisher Scientific CD10 (Membrane Metalloendopeptidase) Recombinant Rabbit Monoclonal Antibody (MME/8658R)
Applications
- Immunohistochemistry (PFA fixed) (IHC (PFA))
Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | MME/8658R |
| Immunogen | Recombinant human CD10 protein fragment (aa 1–500) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD10 (Common Acute Lymphocytic Leukemia Antigen, CALLA) is a cell surface enzyme with neutral metalloendopeptidase activity that inactivates various biologically active peptides. It is expressed on lymphoblastic, Burkitt’s, and follicular germinal center lymphoma cells, immature B cells in adult bone marrow, and cells from patients with chronic myelocytic leukemia (CML). CD10 is also found on breast myoepithelial cells, bile canaliculi, fibroblasts, and highly expressed on the brush border of kidney and gut epithelial cells.
CD10 functions as a neutral endopeptidase, cleaving peptides at the amino side of hydrophobic residues and inactivating peptide hormones such as glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. It is a 100 kDa type II transmembrane glycoprotein encoded by a single-copy gene (~45 kb). The gene’s 5′ untranslated region undergoes alternative splicing, producing four separate mRNA transcripts without affecting the coding region.
Diseases associated with CD10 dysfunction include spinocerebellar ataxia 43 and Charcot-Marie-Tooth disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 없음)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.