Thermo Fisher Scientific MMP2/Collagenase Type IV A (Tumor Metastasis Marker) Monoclonal Antibody (4D3)
인간 MMP2 단백질을 인식하는 단클론성 항체로, 종양 전이 및 조직 재형성 연구에 적합. IHC(PFA 고정)에서 1–2 µg/mL로 검증됨. Protein A/G로 정제된 액상 형태이며, 보존제가 없음. -20°C에서 보관하며 동결·해동 반복을 피해야 함.
- 카탈로그번호
- 4313-MSM4-P1ABX
- 판매단위
- pk
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Applications
- Immunohistochemistry (PFA fixed): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4D3 |
| Immunogen | Recombinant human MMP2 protein fragment (aa557–569) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Matrix metalloproteinases (MMPs) are proteolytic enzymes capable of degrading connective tissue components. They share a conserved activation mechanism and a metal-binding active site region, and are inhibited by tissue inhibitors of metalloproteinases (TIMPs). MMPs and TIMPs regulate angiogenesis and tissue remodeling.
MMP2 is synthesized as a 631-amino-acid proenzyme activated by cleavage of the first 80 amino acids, containing propeptide, catalytic, and hemopexin domains. MMP2 mutations are associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP2 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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