Thermo Fisher Scientific DAGLB Polyclonal Antibody
Rabbit polyclonal antibody against human DAGLB for WB and IP applications. Recognizes residues 622–672 of Diacylglycerol Lipase Beta. Supplied as liquid, 1 mg/mL, stored at 4°C. Ideal for studying endocannabinoid metabolism and lipid signaling.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 622 to 672 of human Diacylglycerol Lipase, Beta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG), which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:14610053).
Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053).
Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses.
Functions also as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages, supporting metabolic and signaling demands of macrophages.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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