Thermo Fisher Scientific ASIC1 Polyclonal Antibody
ASIC1 단백질을 타겟으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, Flow Cytometry에 적합합니다. 인간 시료 반응성이 있으며, 고순도 Affinity chromatography 정제 제품으로 안정적 액상 형태로 제공됩니다.
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Thermo Fisher Scientific ASIC1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within Human ACCN2 aa 457–506 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS (pH 7.4), 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2854698 |
Product Specific Information
Positive Control: SH-SY-5Y, rat brain tissue, mouse brain tissue.
Target Information
ASIC1 (ACCN2) encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. These amiloride-sensitive sodium channels have intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop rich in cysteine residues with conserved spacing.
ASIC1 is expressed in most brain neurons and may function as an ion channel subunit. It is a cation channel with high affinity for sodium, gated by extracellular protons, and inhibited by amiloride. ASIC1 is permeable to Ca²⁺, Li⁺, and K⁺, and is expressed in dorsal root ganglia, sciatic nerves, olfactory bulb, cortical regions, hippocampal formation, amygdaloid nuclei, cerebellar cells, and various basal ganglia regions.
Isoform 3 is expressed only in dorsal root ganglion, while isoform 1 is expressed in DRG, spinal cord, trigeminal ganglia, and trigeminal mesencephalic nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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