Thermo Fisher Scientific Sortilin Polyclonal Antibody
Sortilin 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체. Western blot 및 IHC에 사용 가능하며, rat 유래 합성 펩타이드 면역원으로 제작됨. 단백질 수송 및 신경세포 사멸 연구에 적합. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 – 1:3000 |
| Immunohistochemistry (IHC) | 1:300 – 1:3000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from rat Sortilin conjugated to blue carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1960718 |
Product Specific Information
Reconstitute with 100 µL of distilled water.
The peptide shares 95% identity with mouse’s.
Target Information
Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface.
It is required for protein transport from the Golgi apparatus to the lysosomes by a pathway independent of the mannose-6-phosphate receptor (M6PR).
Sortilin also mediates protein transport from the Golgi apparatus to the endosomes.
It promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB).
Additionally, Sortilin acts as a receptor for neurotensin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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