Thermo Fisher Scientific CTCF Polyclonal Antibody

Applications

Western Blot (WB)

• Assay-dependent

Immunoprecipitation (IP)

• 2–5 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, and Chicken

Target Information

Transcriptional factor CTCF is a ubiquitously expressed 11-zinc finger domain-containing, DNA-binding nuclear phosphoprotein involved in various aspects of normal gene regulation, including transcriptional repression and activation, gene silencing, chromatin insulation, and regulation of imprinted sites.
CTCF interacts with the CCCTC motif on DNA using different combinations of zinc finger domains and can bind to HAT- and HDAC-containing complexes to influence transcriptional activation or repression.
It plays roles in transactivation of the APPB gene, silencing of the c-myc gene, insulation of human beta-globin and DMI myotonic dystrophy loci, and imprinting control of IGF2 and H19 regions.
CTCF also regulates transcription of Pax6 and IRAK2 promoters, suggesting therapeutic potential. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.