Thermo Fisher Scientific KIF1C Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 810-960 of human KIF1C (NP_0066032) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:KIF1C,uniProtId:O43896-1,ncbiNodeId:9606,antigenRange:810-960,antigenLength:1103,antigenImageFileName:PA5-90704_KIF1C_O43896-1_Rabbit.svg,antigenImageFileNamePDP:PA5-90704_KIF1C_O43896-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.73 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2806189

Product Specific Information

Immunogen sequence: EEGGGAGSGG GSEEGARGAE VEDLRAHIDK LTGILQEVKL QNSSKDRELQ ALRDRMLRME RVIPLAQDHE DENEEGGEVP WAPPEGSEAA EEAAPSDRMP SARPPSPPLS SWERVSRLME EDPAFRRGRL RWLKQEQLRL QGLQGSGGRG G; Positive Samples: HeLa, HepG2, 293T, K-562, Mouse brain; Cellular Location: Cytoplasm, cytoskeleton

Target Information

The kinesins constitute a large family of microtubule-dependent motor proteins, which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport, and membrane trafficking events including endocytosis and transcytosis. KIF1C is a member of the KIF1/Unc104 family of kinesin-like proteins, which are involved in the transport of mitochondria or synaptic vesicles in axons. Human KIF1C maps to chromosome 17p13 and encodes a predicted 1,103 amino acid protein with abundant expression in heart and skeletal muscle. Tyrosine phosphorylation is a putative regulator of KIF1C mediated retrograde transport of Golgi vesicles to the endoplasmic reticulum. KIF1C is capable of forming homodimers and can noncovalently associate with 14-3-3 beta, gamma, epsilon and zeta. In mouse macrophages, KIF1C is required for anthrax lethal toxin resistance.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.