Thermo Fisher Scientific POLR3C Polyclonal Antibody
POLR3C 단백질을 인식하는 토끼 유래 다클론 항체로, Western blot과 ELISA에 최적화됨. 인간, 생쥐, 랫트 반응성 확인. 핵 내 RNA polymerase III 복합체 연구에 적합. 액상 형태로 제공되며 -20°C에서 보관.
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Thermo Fisher Scientific POLR3C Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–270 of human POLR3C (NP_0064593) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.68 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806187 |
Product Specific Information
- Immunogen sequence:
MTQAEIKLCS LLLQEHFGEI VEKIGVHLIR TGSQPLRVIA HDTGTSLDQV KKALCVLVQH NLVSYQVHKR GVVEYEAQCS RVLRMLRYPR YIYTTKTLYS DTGELIVEEL LLNGKLTMSA VVKKVADRLT ETMEDGKTMD YAEVSNTFVR LADTHFVQRC PSVPTTENSD PGPPPPAPTL VINEKDMYLV PKLSLIGKGK RRRSSDEDAA GEPKAKRPKY TTDNKEPIPD DGIYWQANLD RFHQHFRDQA IVSAVANRMD QTSSEIVRTM - Positive Samples: Rat ovary
- Cellular Location: Nucleus
Target Information
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
POLR3C is a specific core component of RNA polymerase III, which synthesizes small RNAs such as 5S rRNA and tRNAs.
It may interact with other subunits of RNA Pol III and TFIIIB-DNA complex, contributing to stabilization and initiation of transcription.
POLR3C plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses, acting as a nuclear and cytosolic DNA sensor involved in innate immune response.
It can sense non-self dsDNA that serves as a template for transcription into dsRNA, inducing type I interferon and NF-κB through the RIG-I pathway.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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