Thermo Fisher Scientific POLR3C Polyclonal Antibody

Thermo Fisher Scientific POLR3C Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Immunogen sequence:
  MTQAEIKLCS LLLQEHFGEI VEKIGVHLIR TGSQPLRVIA HDTGTSLDQV KKALCVLVQH NLVSYQVHKR GVVEYEAQCS RVLRMLRYPR YIYTTKTLYS DTGELIVEEL LLNGKLTMSA VVKKVADRLT ETMEDGKTMD YAEVSNTFVR LADTHFVQRC PSVPTTENSD PGPPPPAPTL VINEKDMYLV PKLSLIGKGK RRRSSDEDAA GEPKAKRPKY TTDNKEPIPD DGIYWQANLD RFHQHFRDQA IVSAVANRMD QTSSEIVRTM
• Positive Samples: Rat ovary
• Cellular Location: Nucleus

Target Information

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
POLR3C is a specific core component of RNA polymerase III, which synthesizes small RNAs such as 5S rRNA and tRNAs.
It may interact with other subunits of RNA Pol III and TFIIIB-DNA complex, contributing to stabilization and initiation of transcription.
POLR3C plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses, acting as a nuclear and cytosolic DNA sensor involved in innate immune response.
It can sense non-self dsDNA that serves as a template for transcription into dsRNA, inducing type I interferon and NF-κB through the RIG-I pathway.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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