Thermo Fisher Scientific Sortilin Monoclonal Antibody (CL6528)
Sortilin 단백질을 인식하는 마우스 모노클로날 항체(CL6528). Western blot 및 파라핀 조직 면역조직화학(IHC-P)에 적합. 인간 및 생쥐 시료 반응성. Protein A 정제, 액상 형태, 1 mg/mL 농도. 단기 4°C, 장기 -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL6528 |
| Immunogen | Recombinant protein corresponding to Human SORT1 (amino acids 608–735) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2787074 |
Product Specific Information
Immunogen sequence:
LERNCEEKDY TIWLAHSTDP EDYEDGCILG YKEQFLRLRK SSVCQNGRDY VVTKQPSICL CSLEDFLCDF GYYRPENDSK CVEQPELKGH DLEFCLYGRE EHLTTNGYRK IPGDKCQGGV NPVREVKD
Target Information
Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. It is required for protein transport from the Golgi apparatus to lysosomes and endosomes by a pathway independent of the mannose-6-phosphate receptor (M6PR). Sortilin promotes neuronal apoptosis by mediating endocytosis of proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB), and also acts as a receptor for neurotensin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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