Thermo Fisher Scientific APC1 Polyclonal Antibody
APC1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Western blot 및 Immunoprecipitation에 사용 가능하며, 인간 및 생쥐 반응성을 가집니다. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태로 제공됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 500 and 550 of human anaphase promoting complex subunit 1 (APC1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
Cell cycle regulated protein ubiquitination and degradation within subcellular domains is essential for normal mitosis progression.
APC1 (also known as mitotic checkpoint regulator, MCPR) is a conserved component of the anaphase promoting complex/cyclosome (APC/C), an E3 ubiquitin ligase that controls progression through mitosis and G1 phase.
APC/C degrades anaphase inhibitors, mitotic cyclins, and spindle-associated proteins, ensuring proper mitotic sequence.
APC/C component mRNA and protein levels are expressed at similar levels across tissues and cell lines, indicating their function as part of a complex.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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