Thermo Fisher Scientific B-Myb Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Target Information

Nucleocytoplasmic transport is a signal- and energy-dependent process that occurs through nuclear pore complexes embedded in the nuclear envelope. Import of proteins containing a nuclear localization signal requires the NLS import receptor, a heterodimer of importin alpha and beta subunits (karyopherins). Importin alpha binds the NLS-containing cargo in the cytoplasm, while importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP-binding protein Ran, the complex moves into the nuclear pore complex and dissociates. Importin alpha enters the nucleoplasm with its passenger protein; importin beta remains at the pore. Interactions between importin beta and FG repeats of nucleoporins are essential for translocation through the pore complex. The encoded protein belongs to the importin beta family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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