Thermo Fisher Scientific Bcl-rambo Polyclonal Antibody
Bcl-rambo 단백질을 검출하기 위한 Thermo Fisher Scientific의 폴리클로날 항체. 인간, 마우스, 랫트 반응성. Western blot, IHC, ICC/IF에 적합. 항원 친화 크로마토그래피로 정제된 고순도 액상 항체. 세포 사멸 연구용으로 이상적.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2–4 µg/mL |
| Immunohistochemistry (IHC) | 10 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15 amino acid peptide from near the center of human Bcl-rambo |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage store at −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153477 |
Product Specific Information
- Suggested positive control: K562 cell lysate
- PA5-20000 can be used with blocking peptide PEP-0122
Target Information
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in various diseases such as cancer. Members of the Bcl-2 family are critical regulators of this process and are characterized by conserved Bcl-2 homology (BH) domains.
A novel, widely expressed member termed Bcl-rambo was recently identified. This protein is localized to mitochondria in mammalian cells, and its overexpression induces apoptosis, which can be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2. Bcl-rambo shows homology to anti-apoptotic members containing BH motifs but differs by having a unique 250 amino acid insertion preceding its C-terminal membrane anchor. This region alone can induce apoptosis more efficiently than the BH domains, suggesting that Bcl-rambo may participate in additional pro-apoptotic pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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