Thermo Fisher Scientific CYP11A1 Polyclonal Antibody
CYP11A1 단백질을 특이적으로 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. 고순도 Affinity chromatography 정제, 액상 형태로 안정적 보관 가능. 연구용 전용 시약.
- 카탈로그번호
- PA5102466
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Pig, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CYP11A1 (Accession P05108), corresponding to amino acid residues A411–Q461 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851868 |
Product Specific Information
Antibody detects endogenous levels of total Cytochrome P450 11A1.
Target Information
CYP11A1, also known as cytochrome P450C11A1, cytochrome P450scc, and cytochrome P450 subfamily XIA, catalyzes the first step of steroid biosynthesis under cAMP signal modulation.
In steroidogenic cells, CYP11A1 converts cholesterol to pregnenolone, regulated by hormonal control of cholesterol availability.
Expression of the CYP11A1 gene is controlled by transcription factor SF-1, and its upstream SF-1 binding site is required for hormonal stimulation.
c-Jun and SF-1 may synergistically activate CYP11A1 gene expression. Both Forskolin and 8-Br-cAMPS elevate CYP11A1 mRNA levels in interstitial cell monolayers with functional adenylate cyclase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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