Thermo Fisher Scientific EDN3 Monoclonal Antibody (OTI3E10), TrueMAB

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:150

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional round of desalting (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The protein encoded by the EDN3 gene belongs to the endothelin family. Endothelins are endothelium-derived vasoactive peptides with diverse biological roles.
The active form is a 21-amino acid peptide processed from a precursor protein and acts as a ligand for the endothelin receptor type B (EDNRB).
The EDN3–EDNRB interaction is critical for the development of neural crest-derived cells, including melanocytes and enteric neurons.
Mutations in EDN3 and EDNRB are linked to Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), congenital disorders involving neural crest-derived cells.
Four alternatively spliced transcript variants encoding three distinct isoforms have been identified.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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