Thermo Fisher Scientific Phospho-JAK2 (Tyr1007, Tyr1008) Polyclonal Antibody
JAK2 단백질의 Tyr1007/1008 이중 인산화 부위를 특이적으로 인식하는 폴리클로날 항체. Western blot 및 IHC(P) 적용 가능. 인간과 마우스 반응성. 항원 친화 크로마토그래피로 정제된 고순도 제품으로 연구용으로 적합.
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Thermo Fisher Scientific Phospho-JAK2 (Tyr1007, Tyr1008) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide surrounding the epitope EYYK, with dual phosphorylation sites at Tyr1007 and Tyr1008 of JAK2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 25 mM Tris with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C and avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: GH-stimulated mouse liver
- Cellular location: Cytoplasm
Target Information
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in cytokine receptor signaling pathways and is mutated in polycythemia vera. It contains the catalytic domain (JH1) of JAK2. Activation of JAKs can lead to phosphorylation of STAT (signal transducers and activators of transcription) proteins, which dimerize and translocate to the nucleus to regulate gene transcription. JAK2 is essential for IFN-γ receptor complex initiation, with JAK1 acting as an amplifier. Mutations in JAK2 are associated with disorders such as Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, and Acute myelogenous leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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