Thermo Fisher Scientific RFXANK Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues A(18) S E L G D P E D P G E E A C(31) of human RFX-B. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:RFXANK,uniProtId:O14593-1,ncbiNodeId:9606,antigenRange:18-31,antigenLength:260,antigenImageFileName:PA1-4119_RFXANK_O14593-1_Rabbit.svg,antigenImageFileNamePDP:PA1-4119_RFXANK_O14593-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2179064

Product Specific Information

PA1-4119 detects RFX-B in human samples.

PA1-4119 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~40 kDa protein representing RFX-B in Raji lymphoblastoid cell line.

The PA1-4119 immunogen is a synthetic peptide corresponding to residues A(18) S E L G D P E D P G E E A C(31) of human RFX-B.

Target Information

Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described for this gene, with only one isoform showing activation activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.