Thermo Fisher Scientific KIF3A Polyclonal Antibody
KIF3A 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, Flow cytometry 등에 적합. 고순도 친화 크로마토그래피 정제, 안정적 PBS/glycerol 버퍼 보존. 세포 내 수송 및 신경발생 연구에 활용 가능.
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Thermo Fisher Scientific KIF3A Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within Human KIF3A aa 154–364 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | −20°C, avoid freeze/thaw cycles, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2854702 |
Product Specific Information
Positive Control: Rat testis tissue, Daudi, rat cerebellum tissue, mouse testis tissue, A549.
Target Information
The kinesins constitute a large family of microtubule-dependent motor proteins responsible for the distribution of numerous organelles, vesicles, and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport, and membrane trafficking events including endocytosis and transcytosis.
Members of the heterotrimeric kinesin II family generally contain two different motor subunits from the KIF3 family (KIF3A, KIF3B, KIF3C). KIF3 isoforms mediate anterograde transport of membrane-bound organelles in neurons and melanosomes, transport between the endoplasmic reticulum and the Golgi, and transport of protein complexes within cilia and flagella required for their morphogenesis.
KIF3A may influence neurogenesis at the level of embryonic cellular events, where the asymmetry of the genetic control circuit controlling left-right (L-R) axis determination is defined. Loss of KIF3A function in mouse photoreceptors causes apoptotic cell death, suggesting that kinesin II mediated transport is required for proper cell fate.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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