Thermo Fisher Scientific GCLM Recombinant Rabbit Monoclonal Antibody (ARC0597)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC0597

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 175-274 of human GCLM (P48507) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:GCLM,uniProtId:P48507-1,ncbiNodeId:9606,antigenRange:175-274,antigenLength:274,antigenImageFileName:MA5-37836_GCLM_P48507-1_Rabbit.svg,antigenImageFileNamePDP:MA5-37836_GCLM_P48507-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.25 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2897756

Product Specific Information

Positive Samples: U2OS, HeLa, A-431

Immunogen sequence: LYQWAQVKPN SNQVNLASCC VMPPDLTAFA KQFDIQLLTH NDPKELLSEA SFQEALQESI PDIQAHEWVP LWLLRYSVIV KSRGIIKSKG YILQAKRRGS

Target Information

Gamma-glutamylcysteine synthetase (gamma-GCS) is the rate limiting enzyme for glutathione (L-gamma-glutamyl-L-cysteinylglycine, GSH) synthesis. GSH is ubiquitous in mammalian cells as a vital intra- and extracellular protective antioxidant. Gamma-GCS is a heterodimer of a heavy catalytic subunit and a light regulatory subunit that is responsive to inflammation, phenolic ntioxidants, heat shock, oxidants and cytokines.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.