Thermo Fisher Scientific RARA Monoclonal Antibody (OTI2F1), TrueMAB
RARA 단백질을 인식하는 Mouse Monoclonal Antibody (OTI2F1). Western Blot에 최적화되어 있으며, Human 시료에 반응. 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도. Affinity chromatography로 정제된 고순도 항체.
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Applications
- Western Blot (WB): 1:2,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 52–299 of human RARA produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
RARA (Retinoic Acid Receptor Alpha) is a receptor for retinoic acid. It binds as a heterodimer with RXR to retinoic acid response elements (RAREs) and regulates gene expression in response to all-trans or 9-cis retinoic acid.
In the absence of ligand, RXR–RAR heterodimers repress transcription via corepressor complexes. Upon ligand binding, coactivators are recruited, leading to transcriptional activation.
RARA plays a key role in retinoic acid-induced germ cell development, survival of early spermatocytes, and skeletal growth regulation through chromatin remodeling and gene expression control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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