Thermo Fisher Scientific MGLUR1A/Metabotropic Glutamate Receptor 1a Polyclonal Antibody
mGluR1a 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat, Zebrafish에 반응합니다. IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능하며, 고순도의 Protein A 정제 항체입니다. -20°C 보관, 연구용 전용 제품입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat, Zebrafish |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human MGLUR1A/Metabotropic Glutamate Receptor 1a (amino acids 151–250) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Glutamate is the main excitatory neurotransmitter in the brain. Traditionally, it was known to act on ligand-gated receptor channels such as NMDA, AMPA, and kainate receptors, which mediate fast excitatory synaptic transmission. More recently, glutamate has also been found to regulate enzymes producing second messengers via G-protein–coupled receptors known as metabotropic glutamate receptors (mGluRs).
Group-I receptors (including mGluR1a and mGluR5) stimulate phospholipase C activity, leading to increased phosphoinositide turnover and calcium release from internal stores.
Group-II and Group-III receptors (e.g., mGluR2, mGluR3) are coupled to inhibition of adenylyl cyclase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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