Thermo Fisher Scientific MGLUR3 Polyclonal Antibody
Rabbit polyclonal antibody targeting human mGluR3 (Metabotropic Glutamate Receptor 3). Validated for WB, Flow Cytometry, and ELISA. High specificity and sensitivity with Protein A purification. Supplied in liquid form with 1 mg/mL concentration, ideal ...
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human Metabotropic Glutamate Receptor 3 (amino acids 365–460) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Glutamate is the main excitatory neurotransmitter in the brain. It was traditionally thought to act only on ligand-gated receptor channels (NMDA, AMPA, and kainate receptors) involved in fast excitatory synaptic transmission. Recent studies have shown that glutamate also regulates enzymes producing second messengers via specific G-protein-coupled receptors, known as metabotropic glutamate receptors.
Group-I receptors (mGluR1a and mGluR5) stimulate phospholipase C, leading to increased phosphoinositide turnover and calcium release from internal stores. Group-II and Group-III receptors (including mGluR2 and mGluR3) are coupled to inhibition of adenylyl cyclase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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