Thermo Fisher Scientific CRYAB Monoclonal Antibody (4E8-1C5)
CRYAB 단백질을 인식하는 Mouse monoclonal antibody로 Western blot과 ELISA에 적합. Human 시료에 반응하며, Affinity chromatography로 정제됨. PBS(pH 7.4) buffer에 보존되며, -20°C 보관 권장. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.3 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4E8-1C5 |
| Immunogen | CRYAB (AAH07008, 1–175 a.a) full-length recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
MDIAIHHPWI RRPFFPFHSP SRLFDQFFGE HLLESDLFPT STSLSPFYLR PPSFLRAPSW FDTGLPEMRL EKDRFSVNLD VKHFSPEELK VKVLGDVIEV HGKHEERQDE HGFISREFHR KYRIPADVDP LTITSSLSSD GVLTVNGPRK RVSGPERTIP ITREEKPAVT AAPKK
Target Information
Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found in vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index.
The mammalian lens contains three major classes of crystallins: alpha, beta, and gamma.
- Alpha-crystallin is the largest and composed of alpha-A and alpha-B gene products.
- Beta-crystallins include at least five different proteins.
- Gamma-crystallins are monomeric, with at least five identified in bovine and rat lens.
Alpha-crystallin comprises approximately 40% of total lens protein composition. It also functions as a chaperone-like molecule, preventing aggregate formation that can lead to cataract development. Phosphorylated states of alpha-crystallin may respond to cellular stress, acting in structural control and protein maintenance. Alpha-B crystallin has been associated with Alexander’s disease, where it accumulates in brain cells of affected individuals.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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