Thermo Fisher Scientific SCF Monoclonal Antibody, PeproTech

Applications

Western Blot (WB)

• Tested Dilution: 0.25–0.50 µg/mL

ELISA

• Tested Dilution: 4.0–8.0 µg/mL

Miscellaneous PubMed (Misc)

• Publications: View 1 publication

Product Specifications

Product Specific Information

• AA Sequence of Recombinant Protein:
  MEGICRNRVT NNVKDVTKLV ANLPKDYMIT LKYVPGMDVL PSHCWISEMV VQLSDSLTDL LDKFSNISEG LSNYSIIDKL VNIVDDLVEC VKENSSKDLK KSFKSPEPRL FTPEEFFRIF NRSIDAFKDF VVASETSDCV VSSTLSPEKD SRVSVTKPFM LPPVA

• Preparation:
  Produced in BALB/c mice immunized with highly pure Recombinant Human SCF.
  Anti-Human SCF-specific antibody was purified from cell culture by Protein G affinity chromatography.

Target Information

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF to the c-Kit receptor leads to homodimerization and activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase. SCF expression induces mast cell survival and promotes histamine, pro-inflammatory cytokine, and chemokine release. Inhibition of the SCF/c-Kit pathway reduces histamine levels, mast cell and eosinophil infiltration, IL-4 production, and airway hyperresponsiveness, suggesting therapeutic potential in inflammatory diseases such as asthma.
At least two isoforms of SCF are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.