Thermo Fisher Scientific PDGFRA Monoclonal Antibody (16A1)
인간 PDGFRA(CD140a)를 인식하는 Mouse IgG1 단클론 항체로, 세포면 발현 단백질 분석에 적합합니다. ICC/IF 및 유세포분석(Flow Cytometry)에 사용 가능하며, Protein A로 정제된 액상 형태입니다. 4°C 보관, 비동결.
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Thermo Fisher Scientific PDGFRA Monoclonal Antibody (16A1)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 16A1 |
| Immunogen | CD140a-transfected NIH 3T3 cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11151972 |
Additional Formats
Product Specific Information
This antibody recognizes an extracellular epitope of CD140a / PDGF-RA, the 170 kDa alpha chain of platelet-derived growth factor receptor. It is widely expressed on mesenchymal-derived cells and plays pro-proliferative or anti-proliferative roles in various tumors.
Target Information
PDGFRA is a cell surface receptor tyrosine kinase that binds members of the platelet-derived growth factor family, which are mitogens for mesenchymal-origin cells. The bound growth factor determines whether the receptor forms a homodimer or heterodimer with PDGFRB. Knockout studies show that PDGFRA is crucial for kidney development, as heterozygous mice exhibit defective kidney phenotypes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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