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Thermo Fisher Scientific c-Myc Oncoprotein Monoclonal Antibody ([9E11])
인간 c-Myc 단백질을 인식하는 단클론 항체로, ELISA 등 다양한 연구용 응용에 적합. KLH 결합 합성 펩타이드로 면역화된 Mouse IgG1 항체. 단백질 A/G 정제, PBS 완충액에 0.05% BSA 및 sodium azide 포함. 4°C 보관, 동결 금지.
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Applications
- ELISA (ELISA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | [9E11] |
| Immunogen | A synthetic peptide corresponding to aa 408–439 (AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA) from the C-terminus of human c-Myc, coupled to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | 4°C, do not freeze |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with Mouse, Rat, or Chicken.
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays crucial roles in cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation of c-Myc at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK is associated with regulation of cell proliferation and cycle control.
c-Myc is essential for vasculogenesis and angiogenesis in tumor development. Deregulated expression of c-Myc induces apoptosis and contributes to oncogenesis in multiple tissues.
Amplification or translocation of the c-Myc gene has been implicated in human cancers including lung, breast, colon carcinomas, and Burkitt’s lymphoma.
Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to either amino- or carboxy-termini of target proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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