Thermo Fisher Scientific Phospho-NFkB p100 (Ser870) Polyclonal Antibody
NFkB p100 (Ser870) 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat에 반응. Western blot, IHC, ICC/IF에 사용 가능. 고순도 Affinity chromatography 정제, 안정적인 PBS/glycerol buffer 저장.
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Thermo Fisher Scientific Phospho-NFkB p100 (Ser870) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | References |
|---|---|---|
| Western Blot (WB) | 1:500 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:200 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of serine 870 (Y-G-S(p)-Q-S) derived from Human NFkB p100/p52 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554271 |
Product Specific Information
- Suggested positive control for Western blot: MDA-MB-435 cells
- Suggested positive control for IHC: Human breast carcinoma
- Suggested positive control for ICC/IF: HeLa cells
Target Information
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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