Thermo Fisher Scientific Phospho-NFkB p100 (Ser870) Polyclonal Antibody

Thermo Fisher Scientific Phospho-NFkB p100 (Ser870) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Suggested positive control for Western blot: MDA-MB-435 cells
• Suggested positive control for IHC: Human breast carcinoma
• Suggested positive control for ICC/IF: HeLa cells

Target Information

This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.