Thermo Fisher Scientific CD18 Polyclonal Antibody
CD18 단백질을 표적으로 하는 Thermo Fisher Scientific의 rabbit polyclonal antibody입니다. IHC, ICC/IF, ELISA 등 다양한 응용에 적합하며, 인간·마우스·랫트에 반응합니다. Protein A로 정제된 액상 형태로, -20°C 보관이 권장됩니다.
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Thermo Fisher Scientific CD18 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Integrin beta 2 (amino acids 701–770) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD18 integrin beta 2 subunit is a 90 kDa type I transmembrane protein expressed on all leukocytes.
It forms heterodimers with CD11a–d molecules to constitute leukocyte (beta2) integrins:
- αLβ2 (CD11a/CD18, LFA-1)
- αMβ2 (CD11b/CD18, Mac-1, CR3)
- αXβ2 (CD11c/CD18)
- αDβ2 (CD11d/CD18)
These integrins are essential for proper leukocyte migration and intercellular contact.
Defects in CD18 lead to leukocyte adhesion deficiency type I (LAD1) and may cause psoriasiform skin disease.
CD18 also mediates leukotoxin-induced cytolysis by Mannheimia haemolytica.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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