Thermo Fisher Scientific Sarcomeric Actinin Alpha 2/ACTN2 Monoclonal Antibody (ACTN2/3295)
Human ACTN2 단백질을 인식하는 Mouse monoclonal antibody로 Western blot, IHC 등 다양한 응용 가능. Recombinant fragment (aa557-692)을 면역원으로 사용. 단백질 A/G로 정제된 액상 형태, PBS buffer에 보존. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ACTN2/3295 |
| Immunogen | Recombinant fragment (aa557–692) of human ACTN2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Alpha actinins belong to the spectrin gene superfamily, which represents a diverse group of cytoskeletal proteins including alpha and beta spectrins and dystrophins.
Alpha actinin is an actin-binding protein with multiple roles in different cell types:
- In nonmuscle cells, it is found along microfilament bundles and adherens-type junctions, where it binds actin to the membrane.
- In skeletal, cardiac, and smooth muscle isoforms, it localizes to the Z-disc and analogous dense bodies, anchoring myofibrillar actin filaments.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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