Thermo Fisher Scientific MYBBP1A Polyclonal Antibody

Thermo Fisher Scientific MYBBP1A Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution: 0.2–1.0 µg/mL
Publications: - [References not provided]

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 79% | Dog: 92% | Horse: 92% | Human: 86% | Mouse: 100% | Pig: 92% | Rat: 100%

Target Information

The Myb family of transcription factors, which includes the structurally related A-, B-, and c-Myb genes, regulate differentiation, cellular growth, and transactivating gene expression.
c-Myb plays an essential role in controlling the proliferation and differentiation of hematopoietic cells, with cellular levels of c-Myb decreasing as cells reach terminal differentiation.

Myb-binding protein 1A (MYBBP1A) is a nuclear protein localized predominantly in nucleoli. Although initially isolated as a c-Myb-interacting protein, MYBBP1A is expressed ubiquitously and associates with various transcription factors.
It interacts with the aromatic hydrocarbon receptor (AhR), enhancing transactivation and increasing AhR-dependent gene expression.
MYBBP1A also acts as a negative regulator of PPAR gamma coactivator 1 alpha (PGC-1α) via p38 MAPK and functions as a nucleocytoplasmic shuttling protein utilizing CRM1-dependent and independent nuclear export pathways.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.