Thermo Fisher Scientific CLEC14A Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.1 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

5-15 µg/mL

-

Immunocytochemistry (ICC/IF)

5-15 µg/mL

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Flow Cytometry (Flow)

2.5 µg per million cells

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Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Sheep / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Mouse myeloma cell line NS0-derived recombinant human CLEC14A Glu22-Ala397 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CLEC14A,uniProtId:Q86T13-1,ncbiNodeId:9606,antigenRange:22-397,antigenLength:490,antigenImageFileName:PA5-47677_CLEC14A_Q86T13-1_Sheep.svg,antigenImageFileNamePDP:PA5-47677_CLEC14A_Q86T13-1_Sheep_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2607014

Product Specific Information

In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human (rh) CLEC1, rhCLEC2, rhCLEC3B, and rhCLEC10A is observed.

Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

CLEC-14A (C-type lectin domain family 14 member A), also known as EGFR-5 (epidermal growth factor receptor 5) or CEG1, is a 490 amino acid single-pass type I membrane protein that contains one C-type lectin domain and an EGF-like domain. The gene encoding CLEC-14A maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer`s disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder alpha1-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.