Thermo Fisher Scientific ARC Polyclonal Antibody
ARC 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC/IF에 적합합니다. Human 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능하며, 장기 보관 시 -20°C에서 보관을 권장합니다.
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- PA529389
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region within amino acids 138–192 of Human NOL3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.64 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris Glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546865 |
Product Specific Information
- Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Raji
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
ARC (also known as NOL3 - Nucleolar protein 3) has two isoforms:
- Isoform 1: Involved in RNA splicing
- Isoform 2: Functions as an apoptosis repressor that blocks multiple modes of cell death
ARC inhibits extrinsic apoptotic pathways by:
- Interacting with FAS and FADD upon FAS activation, blocking death-inducing signaling complex (DISC) assembly
- Interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting soluble CASP8 available for DISC-mediated activation
ARC also inhibits intrinsic apoptotic pathways through interactions with BAX, preventing mitochondrial dysfunction and release of pro-apoptotic factors.
Mutations affecting this gene can result in myoclonus, familial cortical disorders.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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