Thermo Fisher Scientific CD4 Monoclonal Antibody (RPA-T4), Alexa Fluor 660, eBioscience
인간 CD4 단백질 인식용 RPA-T4 단일클론 항체로, Alexa Fluor 660 형광 표지되어 있습니다. Flow cytometry에 최적화되어 있으며 HIV 수용체 연구에 유용합니다. 4°C 암소 보관, 동결 금지.
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Thermo Fisher Scientific CD4 Monoclonal Antibody (RPA-T4), Alexa Fluor 660, eBioscience
Applications
- Flow Cytometry (Flow)
Tested Dilution
- 5 µL (0.125 µg)/test
Species Reactivity
- Human
Host / Isotype
- Mouse / IgG1, kappa
Recommended Isotype Control
- Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Alexa Fluor™ 660, eBioscience™
Product Specifications
| 항목 | 내용 |
|---|---|
| Class | Monoclonal |
| Type | Antibody |
| Clone | RPA-T4 |
| Conjugate | Alexa Fluor™ 660 |
| Excitation/Emission Max | 663 / 691 nm |
| Form | Liquid |
| Concentration | 5 µL / Test |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2896239 |
Available Formats
- Unconjugated
- Alexa Fluor 488
- Alexa Fluor 532
- Alexa Fluor 561
- Alexa Fluor 647
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Biotin
- Brilliant UV 496
- Brilliant UV 615
- Brilliant UV 661
- Brilliant UV 737
- Brilliant UV 805
- Brilliant Violet 421
- Brilliant Violet 480
- Brilliant Violet 605
- Brilliant Violet 650
- Brilliant Violet 711
- eFluor 450
- eFluor 506
- FITC
- Functional Grade
- NovaFluor Blue 510
- NovaFluor Blue 585
- NovaFluor Blue 690
- Pacific Orange
- PE
- PE-Cyanine5
- PE-Cyanine5.5
- PE-Cyanine7
- PE-eFluor 610
- PerCP-Cyanine5.5
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 645
- Super Bright 702
- Super Bright 780
- Request custom conjugation
Product Specific Information
The RPA-T4 monoclonal antibody reacts with human CD4, a 59 kDa cell surface receptor expressed by thymocytes, a subpopulation of mature T cells (T-helper cells), and at low levels on monocytes. CD4 acts as a receptor for HIV, and RPA-T4 blocks HIV binding and mixed lymphocyte reaction.
RPA-T4 recognizes a different epitope than OKT4 and does not cross-block binding.
Applications Reported: For flow cytometric analysis.
Applications Tested: Pre-diluted and validated for flow cytometric analysis of normal human peripheral blood cells. Recommended use: 5 µL (0.125 µg) per test in 100 µL final volume, with 10^5–10^8 cells/test.
Alexa Fluor 660 emits at 690 nm, suitable for spectral cytometers multiplexed with APC, Alexa Fluor 647, and Alexa Fluor 700.
Excitation: 662 nm; Emission: 690 nm; Laser: Red Laser
Target Information
CD4 antigen is involved in MHC class II recognition and acts as a co-receptor for HIV. It is primarily expressed on T-helper lymphocytes and also found on monocytes, macrophages, and dendritic cells.
Tissue-level expression includes thymus, lymph nodes, tonsils, spleen, and specific regions of brain and gut.
CD4 functions in early T-cell activation via association with T-cell receptor complex and Lck kinase, and may mediate neuronal damage in immune-related CNS diseases.
Multiple alternatively spliced transcripts have been identified (RefSeq, July 2017).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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