Thermo Fisher Scientific Phospho-Androgen Receptor (Ser94) Polyclonal Antibody
인간 Androgen Receptor의 Ser94 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, Western blot에 최적화됨. 비인간 영장류에도 반응 예측됨. 액상 형태로, Affinity chromatography로 정제. -20°C에서 보관하며, 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser94 of human AR conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.1mg/mL BSA, 0.15M NaCl, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2552696 |
Product Specific Information
- Predicted to react with non-human primate based on 100% sequence homology.
- Contains enough material to conduct 10 mini-Western blots.
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. It is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, AR dissociates from accessory proteins, translocates into the nucleus, dimerizes, and activates transcription of androgen-responsive genes.
AR signaling is crucial for male reproductive organ development and function (prostate, epididymis), and also affects nonreproductive tissues such as muscle, hair follicles, and brain.
Androgen receptor is a phosphoprotein and regulates MAP kinase signaling. Abnormalities in AR signaling are associated with diseases such as prostate cancer, Kennedy’s disease, and male infertility. Mutations can lead to complete androgen insensitivity (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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