Thermo Fisher Scientific GnRHR Monoclonal Antibody (GNRH03)

Applications

Tested Dilution

Publications

Western Blot (WB)

-

View 5 publications 5 publications

Immunohistochemistry (IHC)

-

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:100

View 1 publication 1 publication

Flow Cytometry (Flow)

Assay-dependent

-

Product Specifications

Species Reactivity

Human

Published species

Human, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

GNRH03

Immunogen

A synthetic peptide aa 1-29 (MAN-SASPEQNQNHCSAINNSIPLMQGNLPY) from the N-terminal of human GnRH receptor if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:GnRHR,uniProtId:P30968-1,ncbiNodeId:9606,antigenRange:2,antigenLength:328,antigenImageFileName:MA5-11538_GnRHR_P30968-1_House_mouse.svg,antigenImageFileNamePDP:MA5-11538_GnRHR_P30968-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.4, with 0.2% BSA

Contains

0.09% sodium azide

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10980376

Product Specific Information

MA5-11538 targets GnRH Receptor in FACS, IF, and IHC (P) applications and shows reactivity with Human samples.

The MA5-11538 immunogen is a synthetic peptide aa 1-29 (MAN-SASPEQNQNHCSAINNSIPLMQGNLPY) from the N-terminal of human GnRH receptor.

Target Information

This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5 region and multiple polyA signals in the 3 region have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.