Thermo Fisher Scientific GPR20 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: A549, HeLa, Jurkat, NT2D1
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways.
GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication.
G protein-coupled receptors translate extracellular signals into intracellular signals (G protein activation) and respond to a variety of signaling molecules, such as hormones and neurotransmitters.

GPR20 is a 358 amino acid membrane protein that constitutively activates G(i) proteins without ligand stimulation. It may be involved in the control of intracellular cAMP levels and mitogenic signaling.
GPR20 is expressed in liver and certain regions of the brain, including putamen, caudate, and thalamus, but is not expressed in hypothalamus, pons, and frontal cortex.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.