Thermo Fisher Scientific Glucocorticoid Receptor Polyclonal Antibody
Thermo Fisher Scientific의 Glucocorticoid Receptor Polyclonal Antibody는 인간 및 영장류 시료에 반응하는 sheep 유래 IgG 항체입니다. WB에 적합하며, 정제된 액상 형태로 제공됩니다. 4°C 단기 보관, -20°C 장기 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide consisting of amino acids 150–175 of squirrel monkey glucocorticoid receptor coupled to diphtheria toxoid. This sequence is identical in human glucocorticoid receptor except for 2 amino acids (lowercase): N terminus - APkEKEFPKTHSDVSSEQQnLKGQTG-NH2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Purification | Purified |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1957682 |
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that functions as both a transcription factor and a regulator of other transcription factors.
It forms heteromeric cytoplasmic complexes with heat shock factors and immunophilins. The receptor resides in the cytoplasm until ligand binding induces nuclear transport.
Expression is found in various heart regions including atria, ventricles, aorta, apex, septum, and atrioventricular node.
Alternate splicing and promoter usage result in multiple transcript variants. Mutations in the gene can cause glucocorticoid resistance.
GR requires association with chaperone protein complexes for ligand activation and binds steroids such as dexamethasone with nanomolar affinity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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