Thermo Fisher Scientific CDCA2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human CDCA2, validated for WB and ICC/IF. Synthetic peptide immunogen from residues 950–C-terminus. Detects ~125 kDa protein involved in cell cycle regulation. Suitable for cancer research and chromatin studies.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide conjugated to KLH derived from within residues 950 to the C-terminus of Human CDCA2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_10989873 |
Product Specific Information
PA5-19733 targets CDCA2 in WB applications and shows reactivity with Human samples.
The immunogen is a synthetic peptide conjugated to KLH derived from within residues 950 to the C-terminus of Human CDCA2.
PA5-19733 detects CDCA2, which has a predicted molecular weight of approximately 125 kDa.
Target Information
Cell division cycle associated 2 (CDCA2, Repo-Man) is a cell-cycle protein that recruits protein phosphatase 1 (PP1) to mitotic chromatin at anaphase onset, essential for cell proliferation.
Phosphorylation and dephosphorylation events regulate CDCA2 localization and function, influencing chromatin binding and histone H3 dephosphorylation.
The CDCA2/PP1 complex is also involved in nuclear envelope reformation during mitotic exit and may play a role in DNA repair.
Increased CDCA2 expression has been observed in various cancers, including melanoma, neuroblastoma, squamous cell carcinoma, and synovial sarcoma, suggesting its potential as a prognostic marker.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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