Thermo Fisher Scientific Cofilin Polyclonal Antibody
Cofilin 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat 반응성. 액상형, 0.9 mg/mL 농도, 항원 친화 크로마토그래피로 정제됨. 세포골격 조절 연구에 적합.
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Thermo Fisher Scientific Cofilin Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 1 µg/mL |
| Immunocytochemistry (ICC/IF) | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide conjugated to KLH derived from within residues 150 to the C-terminus of Human Cofilin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.9 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10987446 |
Product Specific Information
- Heat-mediated antigen retrieval recommended prior to tissue staining.
- This antibody is predicted to react with sheep, cow, and pig based on sequence homology.
Target Information
Cofilin binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity.
Regulates actin cytoskeleton dynamics and is essential for normal mitosis and cytokinesis.
Plays a role in cell morphology and cytoskeletal organization.
Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, enhancing chemokine uptake and degradation efficiency.
Involved in neural tube morphogenesis and neural crest cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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