Thermo Fisher Scientific beta Dystroglycan Polyclonal Antibody
Rabbit polyclonal antibody targeting beta Dystroglycan for Western blot applications. Recognizes human and predicted to cross-react with mouse, rabbit, cow, and dog. Purified by antigen affinity chromatography and supplied in PBS with BSA and sodium az...
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Applications
- Western Blot (WB): Tested at 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide conjugated to KLH derived from within residues 650–750 of Human Dystroglycan precursor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.9 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10981547 |
Product Specific Information
This antibody is predicted to react with mouse, rabbit, cow, and dog based on sequence homology.
Target Information
Dystroglycan is a laminin-binding component of the dystrophin-glycoprotein complex that connects the subsarcolemmal cytoskeleton to the extracellular matrix. Dystroglycan 1 is a candidate gene for mutations in autosomal recessive muscular dystrophies. In Duchenne muscular dystrophy, a reduction of dystroglycan 1 disrupts this linkage, making muscle fibers more susceptible to necrosis. Dystroglycan also acts as a dual receptor for agrin and laminin-2 in Schwann cell membranes. Muscle and nonmuscle isoforms differ in carbohydrate moieties but share the same protein sequence. Alternative splicing results in multiple transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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