Thermo Fisher Scientific LAMP2 Recombinant Rabbit Monoclonal Antibody (141)
Recombinant rabbit monoclonal antibody targeting mouse LAMP2/CD107b. Validated for flow cytometry. High purity Protein A-purified IgG in PBS without preservative. Suitable for autophagy and lysosomal research. Store at 4°C short term, -20°C long term.
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- pk
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Thermo Fisher Scientific LAMP2 Recombinant Rabbit Monoclonal Antibody (Clone 141)
Applications
- Flow Cytometry (Flow)
Tested Dilution: 1:25–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 141 |
| Immunogen | Recombinant Mouse LAMP2/CD107b Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2866662 |
Additional Formats
Target Information
LAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) is a member of the lysosomal membrane glycoprotein family. It provides selectins with carbohydrate ligands and may play roles in tumor cell metastasis, lysosomal maintenance, and adhesion.
Prior to post-translational modification, LAMP2 is approximately 46 kDa; mature LAMP2 is extensively glycosylated, reaching 100–130 kDa.
It consists of a large amino-terminal intra-lysosomal domain, a hydrophobic transmembrane domain, and a short cytoplasmic tail.
LAMP2 is a marker for chaperone-mediated autophagy and has three variants: LAMP-2A, -2B, and -2C.
Together with CD107a/LAMP-1, LAMP2 is a major constituent of lysosomal membranes, essential for lysosome–phagosome fusion and phagosomal maturation.
Deficiency of LAMP2 leads to autophagosome accumulation and causes cardiomyopathy and myopathy (Danon’s disease).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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