Thermo Fisher Scientific CD59 Recombinant Rabbit Monoclonal Antibody (108)
Recombinant rabbit monoclonal antibody against mouse CD59a/Protectin. Suitable for flow cytometry with 1:25–1:100 dilution. High purity via Protein A purification. Supplied as liquid, 1 mg/mL, PBS buffer without preservative. For research use only.
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- MA536049
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- pk
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Applications
- Flow Cytometry (Flow)
Tested Dilution: 1:25–1:100
Publications: - References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 108 |
| Immunogen | Recombinant Mouse CD59a/Protectin Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2866661 |
Additional Formats
Target Information
CD59 (Protectin) is a small (18–20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It regulates complement cascade by preventing the formation of cytolytic pores in the plasma membrane. CD59 interacts with C5b-8 complex and inhibits incorporation of C9, crucial for osmolytic pore formation. It also acts as a low-affinity ligand of human CD2, involved in T cell costimulation and lymphocyte signal transduction. Mutations in CD59 cause deficiency leading to hemolytic anemia, thrombosis, and cerebral infarction. Multiple alternatively spliced transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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